what causes white matter disease ?
what causes white matter disease？
White matter disease is a progressive disorder caused by age-related decline in the part of the nerves (the white matter) that connect different areas of brain to each other and to the spinal cord. This disorder can result in memory loss, imbalance and can lead to problems with mobility in older age.
Furthermore,What causes white matter in the brain?
White matter, which lies beneath the gray matter cortex, is composed of millions of bundles of axons (nerve fibers) that connect neurons in different brain regions into functional circuits. The white color derives from the electrical insulation (myelin) that coats axons (see the figure).
In this way,At what age does white matter disease start?
By age 60, this degeneration, termed white matter disease, is present in more than half of the population.
Beside above,How long can you live with white matter disease?
In general, the prognosis is grave, with the majority of patients dying after a few years. However, some die only after several months, and some manage to survive for several decades .
In this regard,How serious is white matter disease?
The life expectancy after a diagnosis of white matter disease depends on the speed it progresses and the severity of any other conditions it may cause, like stroke and dementia. White matter disease is believed to be a factor in both strokes and dementia. However, more research must be done for further confirmation.
White matter lesions (WMLs) are areas of abnormal myelination in the brain. These lesions are best visualized as hyperintensities on T2 weighted and FLAIR (Fluid-attenuated inversion recovery) sequences of magnetic resonance imaging. They are considered a marker of small vessel disease.
Unlike Alzheimer's disease, which shrinks the hippocampus causing progressive memory loss, white matter disease is a more diffuse mind-robbing condition that targets small blood vessels deep within the brain's white matter.
Treatments: While there is no known cure for white matter disease, treatments can help to manage the symptoms. Controlling the risk factors associated with heart disease can help decrease the progression of the disease.
White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure.
It is not possible to stop disease progression, and it is typically fatal within 6 months to 4 years of symptom onset. People with the juvenile form of metachromatic leukodystrophy, which develops between the age of 4 and adolescence, may live for many years after diagnosis.
Sustained attention deﬁcits, executive dysfunction, and memory retrieval deﬁcits are most typical of patients with white matter disorders; all relate to a general slowing of cognition, often called impaired speed of information processing.
Brain scientists have found that white matter disease chips away at memory by shrinking the brain, and contributing to dementia more than initially thought.